Just as a jumbo jet on a flight from Germany to New York is touching down at JFK, something goes terribly wrong. When Ephraim Goodweather, of the Centers for Disease Control, investigates the darkened plane, he finds all but four passengers and crew dead, drained of blood. Despite Goodweather's efforts to keep the survivors segregated, they get discharged into the general population. Soon after, the corpses of the tragedy's victims disappear. The epidemiologist begins to credit the wild stories of Abraham Setrakian, an elderly pawnbroker who's the book's Van Helsing figure, and concludes that a master vampire has arrived in the U.S. The authors maintain the suspense and tension throughout in a tour de force reminiscent of Whitley Strieber's early work.