The book does an excellent job of integrating basic science concepts with clinical medicine. Each of the organ system chapters reviews the normal anatomy, physiology and histology, then follows with the pathophysiology, clinical findings, and pathology of the more commonly encountered disorders. Additionally there are chapters on genetic diseases, immune diseases and neoplasia which similarly link basic science principles with clinical disease entities. Each chapter contains periodic "checkpoint" questions which guide the reader to the most important concepts. Each chapter also ends with several case studies with questions and discussions, similar to those encountered on board examinations.