Beginning with his native Cheshire, it traces his career through Oxford, Padua, Paris, Avignon, Padua again, and finally England, where he spent the last four years of his life trying to fulfil his ambition to serve the commonweal. Most of Starkey's career revolved around his patron Reginald Pole, scion of the highest nobility, but Starkey (and many other Englishmen) managed to balance loyalty to Pole with allegiance to Henry VIII. Out of favour with the king's secretary after the middle of 1536, Starkey turned increasingly to religion, continuing to cling to his conciliarist and Italian Evangelical opinions until his death.