The fifth edition of Management of High-Risk Pregnancy, like its predecessors, is directed to all health professionals involved in the care of women with high-risk pregnancies. The book contains clear, concise, practical material presented in an evidence-based manner. Two series of articles on high-risk pregnancies that appeared in Contemporary OB/GYN were the inspiration for the first edition. These predominantly clinical articles provided a comprehensive perspective on high-risk pregnancy. Now in the fifth edition of Management of High-Risk Pregnancy, I am joined by two outstanding authorities as editors. Catherine Y. Spong, MD is the Chief of the Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development of the National Institutes of Health. Charles J. Lockwood, MD is the Anita O’Keefe Young Professor of Women’s Health and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine. They are both leaders in research and clinical care with national and international reputations. It has been enlightening and rewarding to work with these outstanding colleagues. The content of the fifth edition was designed to provide the necessary background material for decision-making in this area. The topics were selected and then the foremost authority for each subject was invited to write the chapter. Illustrative clinical cases are presented at the end of each chapter. The book contains evidence-based, practical information from outstanding perinatal experts. I welcome the comments of readers, both laudatory and critical. These suggestions will help to improve future editions.