Talk That Counts is a sociolinguistic study of variation in discourse employing quantitative methods to explore age, gender, and social class differences in the use of features such as you know, I mean, adverbs, and pronouns. Unlike many studies of discourse variation that focus on a single social factor, Talk That Counts examines age, gender, and social class differences in a gender-balanced sample of middle-class and working-class adolescents and adults, recorded under the same conditions. Differences between adults and adolescents provided the greatest number of statistically significant results, followed by differences between males and females. The smallest number of statistically significant differences were related to social class. The range of variation underlines the need to look at more than a single extra-linguistic variable when examining discourse. It also shows the dangers of generalizing about social class, for example, on the basis of a limited sample (e.g., adolescent boys). In Talk That Counts, distinguished sociolinguist Ronald Macaulay presents an important new approach to the sociolinguistic investigation of discourse variation.
This blue-ribbon guide has long prevailed as one of the leading resources on Parkinson’s Disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this source promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies for PD
The MRI Atlas of the Spine is the result of an interdisciplinary cooperation between radiologists, orhtopedists and traumatologists. All important diseases and injuries of the spine are covered. Synopsis: This MRI atlas of the spine is the fruit of interdisciplinary cooperation among radiologists, orthopedic surgeons, traumatologists, and neurosurgeons. It is a clinically oriented atlas that covers all important diseases and injuries of the spine. Ample illustrations are supplemented by concise descriptions of anatomy and pathophysiology, the
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry,
Richly illustrated and easy to use, Myelopathy, Radiculopathy, and Peripheral Entrapment Syndromes presents extensive and up-to-date information about the etiopathic and clinical presentation of neurovascular compression insult to the spinal cord, spinal nerve roots, and peripheral nerves. Written with both the student and practitioner in mind, the book covers myelopathy, radiculopathy, and peripheral entrapment syndromes in separate sections, making the information easy to find. Each section includes:oIntroductionoRelevant regional anatomyoPathophysiology and mechanism of the injuryoClinical signs and symptomsoElectrodiagnostic featuresoDiagnostic imagingoSyndromes specific to the level of compromiseMore than 275 detailed, original illustrations and MRIs allow you to visualize the concepts. More than 130 concise tables cover the topic-specific highlights. These two features combine to give the book a quick-reference quality that sets it apart.
