Replicating Vaccines: A New Generation

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, 

When Experiments Travel: Clinical Trials and the Global Search for Human Subjects

The phenomenal growth of global pharmaceutical sales and the quest for innovation are driving an unprecedented search for human test subjects, particularly in middle- and low-income countries. Our hope for medical progress increasingly depends on the willingness of the world's poor to participate in clinical drug trials. While these experiments often provide those in need with vital and previously unattainable medical resources, the outsourcing and offshoring of trials also create new problems. In this groundbreaking book, anthropologist Adriana Petryna takes us deep into the clinical trials industry as it brings together players separated by vast economic and cultural differences.  

Mathematical Finance: Theory, Modeling, Implementation

A balanced introduction to the theoretical foundations and real-world applications of mathematical finance
The ever-growing use of derivative products makes it essential for financial industry practitioners to have a solid understanding of derivative pricing. To cope with the growing complexity, narrowing margins, and shortening life-cycle of the individual derivative product, an efficient, yet modular, implementation of the pricing algorithms is necessary. Mathematical Finance is the first book to harmonize the theory, modeling, and implementation of today's most prevalent pricing models under one convenient cover.

Irish Novels 1890-1940: New Bearings in Culture and Fiction

Studies of Irish fiction are still scanty in contrast to studies of Irish poetry and drama. Attempting to fill a large critical vacancy, Irish Novels 1890-1940 is a comprehensive survey of popular and minor fiction (mainly novels) published between 1890 and 1922, a crucial period in Irish cultural and political history. Since the bulk of these sixty-odd writers have never been written about, certainly beyond brief mentions, the book opens up for further exploration a literary landscape, hitherto neglected, perhaps even unsuspected. This new landscape should alter the familiar perspectives on Irish literature of the period, first of all by adding genre fiction  

Giant Planets of Our Solar System: An Introduction

This book reviews the current state of knowledge of the atmospheres of the giant gaseous planets: Jupiter, Saturn, Uranus, and Neptune. The current theories of their formation are reviewed and their recently observed temperature, composition and cloud structures are contrasted and compared with simple thermodynamic, radiative transfer and dynamical models. The instruments and techniques that have been used to remotely measure their atmospheric properties are also reviewed, and the likely development of outer planet observations over the next two decades is outlined.