Zombies. Mutant animals. Bioengineered weapons and surgically enhanced monsters. Secret labs and widespread conspiracies. It seemed impossible, but Jill Valentine and her teammates among the S.T.A.R.S. had seen it all firsthand when the Umbrella Corporation turned Raccoon City into a staging ground for the most insidious genetic experiments ever conceived. After all she’s been through, Valentine is ready to leave that remote mountain community forever.

Too much evidence of their unethical and immoral research still exists. It must be recovered or destroyed—and quickly—before it can be traced back to Umbrella. And with William Birkin's mutagenic virus already spreading though the city like wildfire, drastic measures are needed. Under cover of night, mercenary teams have entered the city, along with something else—Umbrella's failsafe: an evolved version of its Tyrant-class killing machines, a lethal creature code-named Nemesis. Now Nemesis is on the hunt. And Jill Valentine is about to become prey.

Leon S. Kennedy, Claire Redfield, Rebecca Chambers, and the survivors of the Caliban Cove incident are en route to Europe to rendezvous with the other surviving S.T.A.R.S. members for further operations against the evil Umbrella Corporation. John Andrews and David Trapp, two original characters created for the novels, help fill out the cast. While in the air, their plane is redirected by the mysterious Trent, an enigmatic figure who has been guiding and manipulating events throughout the entire series of novels. Trent informs the group of an Umbrella facility in Utah, used to test and train the company's experimental biological weapons. The facility's overseer, a man named Reston, is one of three people in the world in possession of a codebook which would allow access to all of Umbrella's most secret documents. Trent wants the group to infiltrate the facility, steal the codebook, and take down Umbrella once and for all....