EDITORIAL 12 Promoting Scientific Standards Bruce Alberts NEWS OF THE WEEK 18 Obama Backs New Launcher and Bigger NASA Budget 19 Senate Looms as Bigger Hurdle After Copenhagen 20 Protests by Staff, Advisers Rattle Australian Synchrotron 21 From Science’s Online Daily News Site 22 U.K. Physicists Cry Foul at Major Budget Cuts 22 Errors in Chemistry Claims Cast Doubt on Reactome Paper 23 From the Science Policy Blog 24 Recession Hits Some Sciences Hard at Florida State University 25 Embryo Ruling Keeps Stem Cell Research Legal NEWS FOCUS 26 In the Afterglow of the Big Bang >> Science Podcast LETTERS 30 Bushmeat Hunting and Climate: An Indirect Link P. A. Jansen et al. Gray Wolves Not Out of the Woods Yet J. T. Bruskotter et al. Patents: A Threat to Innovation? M. Manocaran Response S. J. H. Graham and M. J. Higgins Let Top Students Go Forth and Prosper G. Madhavan and B. A. Oakley BOOKS ET AL. 33 Lizards in an Evolutionary Tree J. B. Losos, reviewed by R. G. Gillespie 34 Don’t Be Such a Scientist R. Olson; Am I Making Myself Clear? C. Dean, reviewed by P. Kareiva 34 Browsings POLICY FORUM 36 Opportunities for Research and NIH F. S. Collins PERSPECTIVES 38 Molecular Donuts and Donut Holes K. H. Whitmire >> Report p. 72 39 Serendipitous Astronomy K. R. Lang 41 Janus Catalysts Direct Nanoparticle Reactivity D. J. Cole-Hamilton >> Report p. 68 42 Some Enzymes Just Need a Space of Their Own S. Kang and T. Douglas >> Report p. 81 43 Brain Activity to Rely On? D. S. Schwarzkopf and G. Rees >> Report p. 97 45 Retrospective: Rossiter H. Crozier (1943–2009) J. J. Boomsma and P. Pamilo REVIEW 46 Lipid Rifts As a Membrane-Organizing Principle D. Lingwood and K. Simons BREVIA 51 Masquerade: Camouflage Without Crypsis J. Skelhorn et al. Caterpillars masquerading as twigs are misidentified by chick predators as inanimate objects, rather than remaining undetected. >> Science Podcast RESEARCH ARTICLE 52 Dendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons H. Hu et al. Potassium channel enrichment in the dendrites of hippocampal basket cells defines a mechanism of neural network function. REPORTS 58 An Unusually Fast-Evolving Supernova D. Poznanski et al. The distinctive properties of this supernova suggest that it is of a kind predicted by theory but not previously observed. 60 Polarization-Induced Hole Doping in Wide–Band-Gap Uniaxial Semiconductor Heterostructures J. Simon et al. A compositional gradient of two semiconductors creates an electronic polarization that ionizes and activates dopant atoms. 64 Translocation of Single-Stranded DNA Through Single-Walled Carbon Nanotubes H. Liu et al. Transfer of DNA by electrophoresis through some carbon nanotubes is accompanied by giant current pulses. 68 Solid Nanoparticles That Catalyze Biofuel Upgrade Reactions at the Water/Oil Interface S. Crossley et al. Oxide nanoparticles bearing carbon nanotubes and functionalized with palladium act as both emulsifiers and catalysts. >> Perspective p. 41 72 Unveiling the Transient Template in the Self-Assembly of a Molecular Oxide Nanowheel H. N. Miras et al. Use of a flow reactor reveals a key intermediate in the formation of a molybdenum oxide nanostructure. >> Perspective p. 38 75 Synchronous Deglacial Overturning and Water Mass Source Changes N. L. Roberts et al. Large-scale ocean circulation changed in different ways during a millennial-scale climate event. 78 Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays R. Drmanac et al. A low-cost sequencing technique advances us closer to the goal of the $1000 human genome. 81 Structure and Mechanisms of a Protein-Based Organelle in Escherichia coli S. Tanaka et al. Structures of the shell proteins from a bacterial organelle help to explain how it functions in metabolizing ethanolamine. >> Perspective p. 42 84 The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer E. P. Murchison et al. Sequencing the Tasmanian devil facial tumor disease provides a potential diagnostic marker. >> Science Podcast 88 O-Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding T. Yoshida-Moriguchi et al. A posttranslational sugar modification required to prevent certain dystrophies is identified and characterized. 91 The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana S. Ossowski et al. Rapid sequencing technologies allow a more accurate calculation of the mutation rate for plants. 94 Targeted 3 Processing of Antisense Transcripts Triggers Arabidopsis FLC Chromatin Silencing F. Liu et al. A backward transcript of the FLOWERING LOCUS C gene of Arabidopsis is involved in regulation of the sense-strand transcription. 97 Reproducibility Distinguishes Conscious from Nonconscious Neural Representations A. Schurger et al. Analysis of functional magnetic resonance imaging data reveals that neural activation patterns are more reproducible for seen versus unseen objects. >> Perspective p. 43