This book provides veterinary practitioners and trainees with a concise, systematic guide to urological disorders affecting dogs and cats. The author focuses first on assessment of the patient and the main investigative techniques to reach a diagnosis. He then deals with the differential diagnosis, causes and treatment of conditions ranging from prostate disorders and trauma to all types of urinary incontinence, including urethral sphincter mechanism incompetence. The book is fully referenced and illustrated throughout by color photographs, imaging, and diagrams of the highest quality.
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry,
