Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this debilitating condition. Written and edited by internationally lauded experts in the field, this source covers an expansive array of topics including genetic and causal factors, neuroendocrinology, neurotransmitters and signal transduction pathways, neuroimaging and neurorecognition, and prospects for new treatment development.

Although depression is the most common presentation of bipolar disorder, correct diagnosis generally requires a history of mania and thus presents a formidable challenge. This book provides clinicians with the necessary guidance to distinguish this illness and pursue an appropriate therapeutic course. It brings together a team of clinical investigators who offer cutting-edge research on the topic and address the most critical concerns regarding its treatment.

Bipolar Depression first introduces a hierarchical model for diagnosis to allow the clinician to distinguish between bipolar and unipolar depression, addressing problems of misdiagnosis and overdiagnosis as well as differentiating attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder. Early chapters review the neurobiology and genetics of this highly heritable condition, presenting studies of neurotransmitter function and brain imaging studies and documenting the susceptibility of specific chromosomes as loci for bipolar disorder. Other chapters address the particular issues of bipolar depression in children, for whom a diagnosis is especially problematic, and suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history.

Seven years ago, John McManamy was diagnosed with bipolar disorder. Through his successful Web site and newsletter, he has turned his struggles into a lifelong dedication to helping others battling depression and bipolar disorder reclaim their lives. In Living Well with Depression and Bipolar Disorder, he brilliantly blends the knowledge of leading expert authorities with the experiences of his fellow patients, as well as his own, and offers extensive information on:

    * Diagnosing the problem
    * Associated illnesses and symptoms
    * Treatments, lifestyle, and coping
    * The effects of depression and bipolar disorder on relationships and sex

With a compassionate and eloquent voice, McManamy describes his belief that depression is a wide spectrum that reaches from occasional bouts of depression to full-fledged bipolar disorder. The first book to help patients recognize this diversity of the disorder, Living Well with Depression and Bipolar Disorder will help sufferers begin to reclaim their lives.

Serotonin plays an important role in mediating mood and anxiety disorders. This volume reviews neuronal circuitry relevant to a number of these conditions, such as major depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder and social anxiety. This text addresses the relationship between neuronal circuitry and serotonergic agents and how those agents are effective in the treatment of these disorders. Psychiatrists, neurologists and pharmacologists will benefit from this volume.

This new edition of Dr. Larry Silver’s groundbreaking clinical book incorporates recent research findings on attention-deficit/hyperactivity disorder (ADHD), covering the latest information on diagnosis, associated disorders, and treatment, as well as ADHD in adults. Providing a broad overview of the continuum of neurobiologically based conditions, Attention-Deficit/Hyperactivity Disorder thoroughly reviews disorders often found to be comorbid with ADHD, including specific learning disorders, anxiety disorders, depression, anger regulation problems, obsessive-compulsive disorder, and tic disorders.