The Hand Of Fu-Manchu Being a New Phase in the Activities of Fu-Manchu, the Devil Doctor

The Hand of Fu Manchu (1917) (UK Title: The Si-Fan Mysteries)
Sir Gregory Hale returns to London from Mongolia with a mysterious Tulun-Nur chest that holds the "key to India", a vital secret of the Fu Manchu's notorious Si-Fan organization. Hale is murdered before he is able to disclose the secret to Nayland Smith. The Burmese police commissioner and Dr. Petrie launch a mission to affront the brilliant but deadly master criminal before he succeeds in his malignant and fantastic plot to take over the world.