Bone and Cancer (Topics in Bone Biology)

The book features current knowledge concerning mechanisms of metastasis, the role of the bone microenvironment in cancer progression, function of inflammatory cytokines in metastasis and osteolysis, the role of osteoblasts, thus offering cellular and molecular findings that affect the search for drugs and lead to translational studies. In addition, it contains chapters on animal models for cancer, the molecular imaging of cancer cells, and bone marrow transplants. There are also chapters on bone pain and current therapeutic approaches to secondary bone cancer (i.e. the use of bisphosphonates, chemotherapy, hormone therapy), of particular relevance to the clinician.