The action begins when groundbreaking for an apartment tower in downtown Manhattan reveals a charnel house of murder victims from the late 19th century. Enter Pendergast, who for unexplained reasons taps Kelly to study the remains before the site is stripped by the building's developer, a Donald Trump-type who, with the mayor's backing, will accept no construction delays. As Kelly calls on Smithback for investigative help, the city is struck by killings that duplicate the earlier murders, with the victims' spinal cords ripped away and clues pointing to a 19th-century scientist who sought the secret of immortality.