Taking place seven years after the events of Count Zero and fourteen years after Neuromancer, the story is formed from several interconnecting plot threads, and also features characters from Gibson's previous works (such as Molly Millions, the razor-fingered mercenary street samurai from Neuromancer).
One of the plot threads concerns Mona, an innocent young prostitute who has a more-than-passing resemblance to famed Simstim superstar Angie Mitchell. Mona is hired by shady individuals for a "gig" which later turns out to be part of a plot to abduct Angie.
The second story focuses on a young Japanese girl named Kumiko, daughter of a Yakuza boss sent to London to keep her safe while her father engages in a gang war with other top Yakuza leaders. In London she is cared for by one of her father's retainers, who is also a powerful member of the London Mob.
The third follows a reclusive artist named Slick Henry, who lives in the "Rust Belt," a large, poisoned expanse of deserted factories and dumps somewhere between Cleveland and Chicago, and who is a convicted (and punished) car thief. The final plot line follows Angela Mitchell, famous simstim star and the girl from the second Sprawl novel Count Zero.